Longitudinal echocardiographic parameters before and after pacemaker placement in congenital complete heart block
Authors' conclusion
In 52 paced CCHB subjects, estimated LVEDD z-score decreased significantly after pacemaker placement, and estimated LVSF and LVEF remained within normal limits at 15 years postpacemaker placement.
Study context
- Population
- Paced patients with congenital complete heart block (CCHB)52 with pre- and post-pacemaker echo
- Participants
- 114 patients
- Exposure
- Echocardiographic parameters before vs after pacemaker placement
- Outcome
- Serial changes in left ventricular (LV) size and systolic function (LVEDD z-score, LVSF, LVEF) before and after pacemaker placement
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Estimated left ventricular end-diastolic dimension (LVEDD) z-score at pacemaker placement
- 1.4
- Change in LVEDD z-score per year
- −0.08 (95% CI −0.12 to −0.04; P = .002)
- Estimated LVEDD z-score 15 years postplacement
- 0.2 (95% CI −0.3 to +0.3)
- Change in left ventricular shortening fraction (LVSF) per year from 6 months prepacemaker
- −1.1% (95% CI −1.7% to −0.6%; P <.001)
- Estimated LVSF 4 years postplacement
- 34% (95% CI 32%-37%)
- Estimated left ventricular ejection fraction (LVEF) 15 years postplacement
- 59% (95% CI 55%-62%)
Observational data: associations, not effects.
Further findings
Patient characteristics
- Median age at CCHB diagnosis (IQR 0.0-3.5), years
- 0.6
- Median age at pacemaker placement (IQR 0.5-9.0), years
- 3.4
- Median pacing duration (IQR 5.2-13.7), years
- 10.8
Original publication
Longitudinal echocardiographic parameters before and after pacemaker placement in congenital complete heart block. Heart Rhythm. Published 18 November 2023. doi:10.
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