Arrhythmias & electrophysiology
Low remnant cholesterol and the subsequent risk of new-onset atrial fibrillation: A prospective cohort study
Main finding · Incident AFResult — go to the resultHazard ratio 1.396 95% CI 1.343–1.452Authors' conclusion
Low RC levels were associated with an increased risk of incident AF independent of traditional cardiovascular risk factors.
Study context
- Population
- UK Biobank participants free of atrial fibrillation (AF) at baseline23,558 incident AF
- Participants
- 392,783 participants
- Exposure
- Lower vs highest remnant cholesterol (RC) quartile
- Outcome
- New-onset AF
- Follow-up
- Median 12.8 years (IQR 12.0-13.6 years)
Main finding
Incident AF
Hazard ratio
1.396
95% CI 1.343–1.452
Quartile 1vs Quartile 4
HR 1.396 (95% CI 1.343–1.452)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident AF, discordance analysis (median LDL-C and RC cutoffs)Low RC/low LDL-Cvs High RC/LDL-C | 1.303 (1.260–1.348) | |
| Incident AF, discordance analysis (median LDL-C and RC cutoffs)High RC/low LDL-Cvs High RC/LDL-C | 1.125 (1.079–1.172) | |
| 0.512Hazard ratio (log scale) |
- Incident AF, discordance analysis (median low-density lipoprotein cholesterol (LDL-C) and RC cutoffs) — In low LDL-C group, RC reduction contributed an additional increased rate of incident AF
- 15.8%
Incident AF, discordance analysis (median LDL-C and RC cutoffs)
- Significantly higher AF risk with discordant low RC/high LDL-C vs concordant high RC/LDL-C
Original publication
Low remnant cholesterol and the subsequent risk of new-onset atrial fibrillation: A prospective cohort study. Heart Rhythm. Published 28 May 2024. doi:10.
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