Arrhythmias & electrophysiology
Remnant cholesterol and new-onset atrial fibrillation: The Atherosclerosis Risk in Communities study
Authors' conclusion
Our findings reveal that higher levels of RC, particularly at baseline and in variability, are associated with an increased risk of AF.
Study context
- Population
- ARIC study participants without atrial fibrillation (AF); cohort 1 n = 14,450 (baseline remnant cholesterol (RC)), cohort 2 n = 11,012 (RC variability, cumulative RC, trajectory, V1–V3)2 cohorts: 14,450 and 11,012
- Exposure
- Highest vs lowest quartile/trajectory of remnant cholesterol characteristics
- Outcome
- New-onset AF
- Follow-up
- Median 22.39 years (cohort 1) and 16.71 years (cohort 2)
Main finding
As reported in the abstract
New-onset AF, highest quartile/trajectory
Hazard ratio
1.16
P = 0.039
baseline RC; multivariable-adjusted
Hazard ratio
1.30
P < 0.001
RC variability; multivariable-adjusted
- AF events, cohort 1
- 1993
- AF events, cohort 2
- 1571
Observational data: associations, not effects.
Original publication
Remnant cholesterol and new-onset atrial fibrillation: The Atherosclerosis Risk in Communities study. Heart Rhythm. Published 19 October 2024. doi:10.
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