Coronary disease & ACSCohort study
Macrotroponin Complexes and Risk of Cardiovascular Events
- Prospective cohort study
- general population cohort
- replication cohort
Authors' conclusion
Assay interference due to macrotroponin complex formation is common in individuals with elevated cardiac troponin concentrations in the general population, particularly for cardiac troponin I.
Study context
- Population
- General population participants with both cardiac troponin I and T measured; median age 49 years, 58.3% women
- Participants
- 19,499 participants
- Exposure
- Suspected macrotroponin and myocardial injury vs no myocardial injury
- Outcome
- Future MI, ischemic stroke or CV death
Main finding
As reported in the abstract
MI, ischemic stroke or CV death
Each group vs no myocardial injuryAdjusted hazard ratio (95% CI)
Myocardial injurycardiac troponin I
2.90(1.99–4.22)
Myocardial injurycardiac troponin T
1.99(1.63–2.42)
Suspected macrotroponinmacrotroponin I
1.59(0.94–2.70)
Suspected macrotroponinmacrotroponin T
1.27(1.00–1.61)
Observational data: associations, not effects.
Further findings
Prevalence of elevated troponin and discordance
- Elevated cardiac troponin I
- 1% (193 of 19 499)
- Elevated cardiac troponin T
- 6% (1159 of 19 499)
- Discordant among elevated troponin I
- 48%
- Discordant among elevated troponin T
- 57%
Discordant troponin attributed to macrotroponin complexes (biochemical testing, subset n=203)
- Discordant troponin I
- 92.5%
- Discordant troponin T
- 15.4%
Original publication
Macrotroponin Complexes and Risk of Cardiovascular Events. Circulation. Published 8 September 2026. doi:10.1161/circulationaha.126.080483
Summarised from the published abstract; every number is checked against it