Heart failure & cardiomyopathies
Magnetic Resonance Imaging in the Assessment of the Risk of Sudden Death in Cardiac Sarcoidosis: What Is Extensive or Significant Late Gadolinium Enhancement?
Authors' conclusion
In cardiac sarcoidosis, myocardial LGE making up ≥9.9% of LV mass or affecting ≥6 LV segments may suggest prognostically significant LV involvement and a high risk of SCD.
Study context
- Population
- Patients with clinically manifest, definite or probable cardiac sarcoidosis with CMR before or <3 months after diagnosismedian follow-up 4.0 years
- Participants
- 305 patients
- Exposure
- Late gadolinium enhancement (LGE) extent on CMR
- Outcome
- Composite of fatal or aborted SCD and VT prompting therapy
Methodological detailsnationwide registry
- Nationwide registry
Main finding
As reported in the abstract
SCD/VT
- Both LGE mass and number of LGE segments predicted sudden cardiac death (SCD)/ventricular tachycardia (VT)
- P<0.001
- Events on follow-up: SCDs
- 21
- Events on follow-up: VTs
- 60
- Competing events
- 14
Observational data: associations, not effects.
Further findings
| Outcome | LGE mass <9.9% | LGE mass ≥9.9% | <6 LGE segments | ≥6 LGE segments |
|---|---|---|---|---|
| 5-year SCD/VT in patients without LGE-unrelated class I/IIa ICD indications (n=70) | 6.3% (interval 0.0–14.8%) | 21.5% (interval 6.5–36.6%) | 6.9% (interval 0.0–16.3%) | 20.5% (interval 5.9–35.2%) |
Original publication
Magnetic Resonance Imaging in the Assessment of the Risk of Sudden Death in Cardiac Sarcoidosis: What Is Extensive or Significant Late Gadolinium Enhancement? Circ Arrhythm Electrophysiol. Published 20 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →