Arrhythmias & electrophysiology
Marshall-Plan Ablation Strategy Versus Pulmonary Vein Isolation in Persistent Atrial Fibrillation (AF): A Randomized Controlled Trial
Authors' conclusion
In this prospective randomized controlled trial, the Marshall-Plan strategy was significantly superior to a PV isolation strategy at 12 months.
Study context
- Population
- Consecutive patients with symptomatic, documented persistent AFincluded (age 65±8 years, 21 women), two patients excluded from analysis
- Participants
- 120 patients
- Comparison
- Marshall-Plan versus pulmonary vein (PV) isolation alone
- Marshall-Plann = 59
- PV isolationn = 59
- Primary endpoint
- Freedom from any arrhythmia (atrial fibrillation/atrial tachycardia >30 seconds) after a single ablation procedure with or without any antiarrhythmic medication
- Follow-up
- 12 months
Methodological detailsconducted at the Bordeaux University Hospital
- Conducted at the Bordeaux University Hospital
Primary result
As reported in the abstract
P = 0.012
Further findings
| Outcome | Marshall-Plan | PV isolation |
|---|---|---|
| Procedural results | ||
| Vein of Marshall ethanol infusion completed | 57 (97%) | — not stated in the abstract |
| Conduction block, mitral isthmus | 93% | — not stated in the abstract |
| Conduction block, dome | 92% | — not stated in the abstract |
| Conduction block, cavotricuspid isthmus | 93% | — not stated in the abstract |
| Full lesion set completed | 52 (88%) | 59 (100%) |
— not stated in the abstract
Procedural results
- All PVs were successfully isolated in both groups
Original publication
Marshall-Plan Ablation Strategy Versus Pulmonary Vein Isolation in Persistent AF: A Randomized Controlled Trial. Circ Arrhythm Electrophysiol. Published 20 May 2025. doi:10.
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