Heart failure & cardiomyopathies
Mechanical Dyssynchrony as a Selection Criterion for Cardiac Resynchronization Therapy: Design of the AMEND-CRT Trial
Study context
- Population
- Patients scheduled for cardiac resynchronization therapy (CRT) according to the 2021 ESC guidelinesplanned
- Participants
- 578 patients
- Planned comparison
- Echo-guided CRT activation vs guideline-based CRT
- Primary endpoint
- Average change in LV end-systolic volume and patient outcome by modified Packer Clinical Composite Score
- Follow-up
- 1 year
Methodological detailsdesign paper, multicentre, parallel-group, double-blind, sham-controlled, non-inferiority, 1:1 randomisation; all participants receive a device
- Design paper
- Multicentre
- Parallel-group
- Double-blind
- Sham-controlled
- Non-inferiority
- 1:1 randomisation; all participants receive a device
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Mechanical Dyssynchrony as a Selection Criterion for Cardiac Resynchronization Therapy: Design of the AMEND-CRT Trial. ESC Heart Fail. Published 10 July 2024. doi:10.
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