Heart failure & cardiomyopathies
Impact of glomerular filtration rate estimation formulas on MECKI score performance and prognostic accuracy in heart failure: the MECKI-RENAL study
Authors' conclusion
GFR estimations play a role in HFrEF prognosis without difference among the 6 most frequently used formulas. Furthermore, using eGFR calculated from the 6 different formulas in MECKI score did not significantly alter its strong prognostic power, highlighting MECKI reliability in risk stratification.
Study context
- Population
- Heart failure (HF) patients with reduced ejection fraction (HFrEF) enrolled in the MECKI score databasepatients enrolled in the MECKI score database
- Participants
- 6,933 patients
- Comparison
- Prognostic accuracy of 6 glomerular filtration rate estimation (eGFR) formulas in HF patients with reduced ejection fraction (HFrEF) and their impact on the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score prognostic accuracy
- Outcome
- Composite of:
- Cardiovascular death
- Left ventricular assist device implantation
- Urgent heart transplantation
- Follow-up
- 2 years
Main finding
As reported in the abstract
European Kidney Function Consortium (EKFC)
0.6271
AUC
Modification of Diet in Renal Disease (MDRD)
0.635
AUC
Further findings
Prevalence of severe CKD (eGFR <30 mL/min/1.73 m²)
Cardiovascular death
- AUC range
- 0.668 to 0.677
MECKI score AUC for prognosis with each formula
- MECKI AUC range
- 0.7841 to 0.7883
- EKFC and CKD-EPI showing the best performance
Original publication
Impact of glomerular filtration rate estimation formulas on MECKI score performance and prognostic accuracy in heart failure: the MECKI-RENAL study. Eur Heart J Qual Care Clin Outcomes. Published 13 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it