Arrhythmias & electrophysiology
Mediterranean diet and epicardial adipose tissue in patients with atrial fibrillation treated with ablation: a substudy of the ‘PREDIMAR’ trial
Authors' conclusion
In patients with AF, higher adherence to MedDiet is associated with a significantly lower amount of EAT. Epicardial adipose tissue ≥ 135 g was significantly associated with persistent AF.
Study context
- Population
- Patients with atrial fibrillation (AF) treated with ablation, with CT epicardial adipose tissue (EAT) measurement
- Participants
- 199 patients
- Comparison
- Mediterranean diet (MedDiet) adherence and EAT ≥ 135 g
- Primary endpoint
- Association of MedDiet adherence with EAT; association of EAT with AF type at baseline; associations with AF recurrence after ablation (any documented AF > 30 s)
Methodological detailssingle-centre, cross-sectional and prospective analyses
- Single-centre
- Cross-sectional and prospective analyses
Primary result
As reported in the abstract
EAT and MedDiet adherence (whole cohort); associations with EAT and persistent AF · baseline
mOR (95% CI)P value
MEDAS ≥ 7odds of EAT ≥ 135 g
0.45(0.22–0.91)
P = 0.025EAT ≥ 135 gpersistent AF, adjusted for traditional risk factors
2.22(1.03–4.79)
P = 0.042- Median EAT, g (IQR 112-177)
- 135
- Mean MedDiet score, points (± 2)
- 7.75
Further findings
Atrial tachyarrhythmia / AF recurrence after ablation
| mHR (95% CI) | P value | |
|---|---|---|
| EAT ≥ 135 gAtrial tachyarrhythmia recurrence · Cox regression, multivariable-adjusted | 1.18 (0.72–1.94) | P = 0.512 |
| MEDAS ≥ 7AF recurrence · Cox regression, multivariable-adjusted | 0.78 (0.47–1.31) | P = 0.344 |
Original publication
Mediterranean diet and epicardial adipose tissue in patients with atrial fibrillation treated with ablation: a substudy of the ‘PREDIMAR’ trial. Eur J Prev Cardiol. Published 10 November 2023. doi:10.
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