Acute cardiac care & resuscitation
Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial
Authors' conclusion
Shock severity, allocation to mAFP, and device-related complications were associated with an increased risk of AKI. AKI was generally associated with higher mortality, but the allocation to mAFP consistently led to lower mortality rates at 180 days irrespective of the occurrence of AKI with or without RRT initiation.
Study context
- Population
- Adults with STEMI-related cardiogenic shock
- Participants
- 355 adults
- Comparison
- Microaxial flow pump (mAFP) vs standard care alone
- mAFPn = 179
- Standard caren = 176reference
- Primary endpoint
- Rates and predictors of AKI (RIFLE criteria) and RRT
Methodological detailsprespecified analysis, international, open-label, multicentre
- Prespecified analysis
- International
- Open-label
- Multicentre
Primary result
As reported in the abstract
AKI (RIFLE ≥1)
P < 0.01
Further findings
RRT
P < 0.01
RRT initiated within first 24 h from admission · first 24 hours · % of RRTs
| Outcome | Subdistribution hazard (CI) |
|---|---|
| RRT | 1.67 (1.18–2.35) |
- RRT: accounting for competing risk of death; largely consistent among prespecified subgroups
180-day mortality by acute kidney injury (AKI)/RRT
- mAFP associated with lower 180-day mortality irrespective of AKI or RRT
- P for interaction = 0.84
- AKI and RRT associated with higher 180-day mortality in both arms
- All patients alive at 180 days free of RRT
Predictors of AKI
- Both groups: reduced LVEF, baseline kidney function, shock severity, bleeding events, positive fluid balance
- mAFP-specific: suction events, higher pump speed, longer duration of support
Original publication
Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial. Circulation. Published 27 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →