Heart failure & cardiomyopathies
MicroRNA-30d and -483-3p for Bi-Ventricular Remodelling and miR-126-3p for Pulmonary Hypertension in Advanced Heart Failure
Authors' conclusion
In patients with DCM, few miRNAs are co-expressed in serum and tissue: They are related to LV remodelling (miR-30d), post-capillary pulmonary artery pressure (miR-126-3p), and right ventricular remodelling/filling pressures (miR-483-3p).
Study context
- Population
- End-stage HFrEF (DCM or ischaemic cardiomyopathy) referred for continuous flow left ventricular (LV) assist device implant
- Participants
- 10 vs 3
- Exposure
- DCM vs Ischaemic cardiomyopathy
- DCMn = 10
- Ischaemic cardiomyopathyn = 3
- Outcome
- Serum–LV tissue co-expressed miRNAs (754-miRNA panel) and correlations with echocardiographic and haemodynamic measures
Main finding
As reported in the abstract
- miR-30d vs LV systolic volume
- r = 0.78, P = 0.001
- miR-30d vs LV diastolic volume
- r = 0.80, P = 0.005
- miR-126-3p vs mPAP
- r = −0.79, P = 0.007
- miR-126-3p vs PCWP
- r = −0.80, P = 0.005
- Serum miR-483-3p vs RV end diastolic diameter
- r = −0.73, P = 0.02
- Serum miR-483-3p vs central venous pressure
- r - 0.68 p 0.03
Observational data: associations, not effects.
Original publication
MicroRNA-30d and -483-3p for Bi-Ventricular Remodelling and miR-126-3p for Pulmonary Hypertension in Advanced Heart Failure. ESC Heart Fail. Published 21 October 2023. doi:10.
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