Arrhythmias & electrophysiology
Microvascular disease, modifiable risk factor profiles and incident arrhythmias in type 2 diabetes
Authors' conclusion
Although microvascular disease, a non-traditional risk factor, was associated with incident arrhythmias in individuals with T2D, having optimal levels of risk factors may mitigate this risk.
Study context
- Population
- Participants with T2D free of arrhythmias at recruitment, UK Biobank
- Participants
- 25,632 participants
- Exposure
- Microvascular disease vs no microvascular disease, by number of optimal modifiable risk factors
- Microvascular diseasen = 8,482
- Without microvascular diseasen = 17,150reference
- Outcome
- Incident arrhythmias
- Follow-up
- Median 12.3 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
- Any of the three microvascular diseases associated with increased hazard of arrhythmias
- 48%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Arrhythmias, joint association of microvascular disease and number of optimal arrhythmic risk factors (BMI, smoking, SBP, HbA1c)Microvascular disease, zero to one optimal risk factorvs Without microvascular disease | 2.05 (1.85–2.27) | |
| Arrhythmias, joint association of microvascular disease and number of optimal arrhythmic risk factors (BMI, smoking, SBP, HbA1c)Microvascular disease, two optimal risk factorsvs Without microvascular disease | 1.67 (1.53–1.83) | |
| Arrhythmias, joint association of microvascular disease and number of optimal arrhythmic risk factors (BMI, smoking, SBP, HbA1c)Microvascular disease, three optimal risk factorsvs Without microvascular disease | 1.35 (1.22–1.50) | |
| Arrhythmias, joint association of microvascular disease and number of optimal arrhythmic risk factors (BMI, smoking, SBP, HbA1c)Microvascular disease, four optimal risk factorsvs Without microvascular disease | 0.91 (0.73–1.13) | |
| 0.512Hazard ratio (log scale) |
Arrhythmia prediction
- Adding microvascular disease states to a model with 11 traditional risk factors significantly enhanced arrhythmia prediction
Original publication
Microvascular disease, modifiable risk factor profiles and incident arrhythmias in type 2 diabetes. Heart. Published 21 March 2024. doi:10.
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