Valvular & structural heart disease
Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry
Authors' conclusion
MR degree variation is common after TTVI, with most cases showing improvement. Clinical and procedural characteristics may predict the MR evolution, in particular procedural success and T-TEER play key roles in MR outcomes.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) treated with transcatheter tricuspid valve interventions (TTVI), mostly T-TEER; excluding concomitant mitral transcatheter intervention or prior mitral valve intervention80% T-TEER
- Participants
- 359 patients
- Primary endpoint
- MR improvement and worsening (co-primary)
- Follow-up
- pre-discharge and 2-month follow-up
Methodological detailsinternational registry
- International registry
Primary result
As reported in the abstract
Mitral regurgitation (MR) improvement, pre-discharge
106
29.5%
MR improvement, 2-month follow-up
99
34%
MR worsening, pre-discharge
34
9.5%
MR worsening, 2-month follow-up
33
11%
Further findings
Predictors of MR evolution
- Annuloplasty and heterotopic replacement associated with MR worsening
- Independent predictors of MR improvement: AF, T-TEER, acute procedural success, TR reduction, LV end-diastolic diameter >60 mm, beta-blocker therapy
Death by post-TTVI MR grade
- Moderate-to-severe/severe MR after TTVI: significantly higher death rates
Original publication
Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry. Eur Heart J Cardiovasc Imaging. Published 27 August 2024. doi:10.
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