Valvular & structural heart disease
Mitral valve early systolic billowing induces following annular expansion and leaflet augmentation in Barlow’s disease: sequential analysis using 3D echocardiography
Authors' conclusion
In Barlow's disease, early systolic billowing of the mitral leaflet induces systolic annulus expansion followed by leaflet augmentation and leaflet free-edge prolapse.
Study context
- Population
- Patients with Barlow's disease and severe mitral regurgitation without torn chordae
- Comparison
- Barlow's disease vs controls
- Barlow's diseasen = Fifty-three
- Controlsn = 10reference
- Outcome
- Mitral apparatus dynamics during systole (Barlow's disease)
Methodological detailsframe-by-frame sequential geometric analysis, real-time 3D transoesophageal echocardiography
- Frame-by-frame sequential geometric analysis
- Real-time 3D transoesophageal echocardiography
Main finding
As reported in the abstract
Prolapse volume of both leaflets, early to mid-systole, median (range as printed)
1.60 (0.85-2.80) to 4.00 (2.10-6.45) mL; ANOVA P < 0.001; post hoc P < 0.05
Dynamic augmentation of annulus and leaflets between frames just before and just after leaflet free-edge prolapse
ANOVA P < 0.01; post hoc P < 0.05
Original publication
Mitral valve early systolic billowing induces following annular expansion and leaflet augmentation in Barlow’s disease: sequential analysis using 3D echocardiography. Eur Heart J Cardiovasc Imaging. Published 30 January 2024. doi:10.
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