Mortality After Major Cardiovascular Events in Survivors of Childhood Cancer
Authors' conclusion
Survivors of childhood cancer represent a population at high risk for mortality after major cardiovascular events.
Study context
- Population
- Adult survivors of childhood cancer with a major CV event (heart failure (HF), coronary artery disease (CAD) or stroke)1,780 survivors and 91 siblings had a CV event
- Participants
- 25,658 / 5,051 / 5,114
- Exposure
- Childhood cancer survivors vs siblings and CARDIA participants
- Survivorsn = 25,658
- Siblingsn = 5,051reference
- CARDIAn = 5,114reference
- Outcome
- All-cause and CV cause-specific mortality after HF, CAD or stroke
Main finding
As reported in the abstract
All-cause mortality after a major CV event · 10 years
Survivors
1,780
events
Siblings
91
events
Survivors vs SiblingsHazard ratio (95% CI)
All-cause mortality after HF
7.32(2.56–20.89)
All-cause mortality after CAD
5.54(2.37–12.93)
All-cause mortality after stroke
3.57(1.12–11.37)
- CAD-specific mortality risk increased
- HR: 3.70; 95% CI: 1.05-13.02
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortalityvs CARDIA participantsAll-cause mortality after CAD | 1.85 (1.16–2.95) | |
| 0.20.5125Hazard ratio (log scale) |
Mortality vs CARDIA participants
- Mortality risks otherwise similar vs CARDIA (CARDIA median age at events 57 vs 31 years; 345 CARDIA participants had a major event)
Original publication
Mortality After Major Cardiovascular Events in Survivors of Childhood Cancer. J Am Coll Cardiol. Published 27 February 2024. doi:10.
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