Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors
Authors' conclusion
A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell's criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%.
Study context
- Population
- Long-term childhood cancer survivors undergoing ECG and echocardiography; prediction models in 880 survivors who received anthracycline, mitoxantrone or heart radiotherapy880 survivors in prediction models
- Participants
- 1,381 vs 272
- Exposure
- Childhood cancer survivors vs siblings; ECG-augmented vs baseline clinical prediction models for abnormal left ventricular ejection fraction (LVEF)
- Survivorsn = 1,381
- Siblingsn = 272reference
- Outcome
- Prevalence of ECG abnormalities (Minnesota Code) and their diagnostic value for abnormal LVEF (<52% male/<54% female, <50%, <45%)
Main finding
As reported in the abstract
Major ECG abnormalities
- Sex-specific abnormal LVEF: c-statistic baseline vs with ECG
- 0.66 vs 0.71
- LVEF <50%: c-statistic baseline vs with ECG
- 0.66 vs 0.76
- LVEF <45%: c-statistic baseline vs with ECG
- 0.80 vs 0.86
- LVEF <45% model (5 ECG variables) for ruling out: sensitivity
- 93%
- LVEF <45% model: specificity
- 56%
- LVEF <45% model: NPV
- 99.6%
Observational data: associations, not effects.
Original publication
Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors. Heart. Published 19 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →