Coronary disease & ACSCohort study
Mosaic loss of Y chromosome and mortality after coronary angiography
- Cohort study with mechanistic analyses
Authors' conclusion
LOY represents an important independent risk factor for cardiovascular mortality in male patients with coronary artery disease.
Study context
- Population
- Male participants of the LURIC study undergoing coronary angiographyLURIC study, males
- Participants
- 1,698 participants
- Exposure
- LOY >17% vs lower LOY
- Outcome
- CV mortality
Main finding
As reported in the abstract
LOY > 17% vs LOY ≤ 17%Hazard ratio (95% CI)
CV mortality
1.49(1.09–2.03)
all-cause mortality
1.41(1.09–1.82)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Fatal MI | 2.65 (1.46–4.81) | |
| 0.20.5125Hazard ratio (log scale) |
Plasma proteins
- LOY > 17% associated with profibrotic, proinflammatory profile (higher osteoprotegerin, MMP-12, GDF-15, HB-EGF, resistin)
Genetic predisposition for lower myocardial fibrosis
- Attenuated the association between LOY and CV mortality
Genome-wide methylation and single-cell RNA sequencing
- Genes with differential methylation
- 298
- Genes with confirmed differential expression in PBMCs with LOY
- 37
Original publication
Mosaic loss of Y chromosome and mortality after coronary angiography. Eur Heart J. Published 12 February 2025. doi:10.1093/eurheartj/ehaf035
Summarised from the published abstract; every number is checked against it