Multi-modality non-invasive cardiovascular screening and sex-specific outcomes: the Viborg Screening Program
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.76 95% CI 0.68–0.85Authors' conclusion
Multi-modality non-invasive cardiovascular screening reduced 5-year all-cause mortality among 67-year olds, also when stratified by sex.
Study context
- Population
- 67-year olds in Denmark, invitees 2014–20195,505 invitees
- Participants
- 5,412 vs 16,236
- Exposure
- Invitation to multi-modality CV screening vs no screening access
- Inviteesn = 5,412
- Controlsn = 16,236reference
- Outcome
- All-cause mortality
- Follow-up
- Median 5.8 years
Methodological detailspropensity-score matched (1:3, nearest-neighbour), intention-to-invite analysis, post hoc sex-stratified analyses
- Propensity-score matched (1:3, nearest-neighbour)
- Intention-to-invite analysis
- Post hoc sex-stratified analyses
Main finding
As reported in the abstract
Hazard ratio
0.76
95% CI 0.68–0.85
P < 0.001
Events by group
Inviteesvs Controls
HR 0.76 (95% CI 0.68–0.85); P < 0.001
- Number needed to invite to save one life
- 49
Observational data: associations, not effects.
Further findings
CV mortality
- HR, CV mortality
- 0.76 (95% CI 0.56-1.03)
MACE
- HR, MACE
- 1.10 (95% CI 1.01-1.19)
Major adverse limb events
- HR, major adverse limb events
- 0.70 (95% CI 0.50-0.98)
All-cause mortality, by sex (subgroup)
- HR, men
- 0.73 (95% CI 0.63-0.84)
- HR, women
- 0.82 (95% CI 0.68-0.98)
- Post hoc sex-stratified analyses
All-cause mortality, by prior cardiovascular disease (CVD) (subgroup)
- HR, no prior CVD
- 0.70 (95% CI 0.61-0.80)
- HR, prior CVD
- 0.97 (95% CI 0.78-1.21)
Original publication
Multi-modality non-invasive cardiovascular screening and sex-specific outcomes: the Viborg Screening Program. Eur Heart J. Published 28 April 2026. doi:10.
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