Arrhythmias & electrophysiology
Multicenter Results of a Novel Pediatric Pacemaker in Neonates and Infants
Authors' conclusion
The pediatric implantable pulse generator can be safely implanted in neonates and infants. This multicenter report demonstrates that the devices remain stable, with effective pacing, normal electrical parameters, and battery longevity aligned with projections. This novel pediatric pacemaker provides a viable alternative to standard-size generators and addresses a vital unmet need for these small patients.
Study context
- Population
- Neonates and infants who underwent implantation of a pediatric implantable pulse generator (Medtronic Micra subassembly in a polymer header connecting to a bipolar epicardial lead), March 2022 to February 2024all patients at 12 sites within the timeframe
- Participants
- 29 neonates
- Outcome
- Device parameters (most recent)
- Follow-up
- Average duration of implant 325 days (73-808 days)
Methodological detailsdeidentified data, 12 of 15 sites in the United States
- Deidentified data
- 12 of 15 sites in the United States
Main finding
As reported in the abstract
Lead impedance mean
612 ohms
450–840 ohms
Ventricular capture threshold mean
1 V @ 0.4 ms
range, 0.38–2.75 V
R-wave sensing mean
12.5 mV
3.6–20 mV
Further findings
Generator explants · removed at 6.5 to 31 months of age
- Generator explants
- 7 (24%)
Baseline characteristics · at implant
- Median age at implant
- 15 days (range, 0 days to 3 years, including 1 outlier)
- Median weight
- 2.3 kg (range, 1.3-11.4 kg)
- Gestational age
- 28.5 weeks to term
- Born prematurely
- 23 (79%)
- Congenital heart disease, of those with anatomic information
- 25%
Original publication
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