Cardio-oncology & otherMeta-analysis
Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence
- Epigenome-wide association study
- multicohort
- 2-stage strategy
- meta-analysis
Authors' conclusion
These results point to molecular pathways and potential treatments for precision prevention of CVD and cancer.
Study context
- Population
- 3 ethnically diverse cohorts: Native Americans (SHS), European Americans (FHS), European Americans and African Americans (ARIC)
- Outcome
- Common epigenetic signatures (DMPs) for CVD and cancer incidence
Pooled result
As reported in the abstract
DMPs significant in meta-analysis
Differentially methylated positions (DMPs) significant for cardiovascular disease (CVD) only
3
DMPs significant for both cancer and CVD
1
Further pooled results
C index for incident cancer in SHS participants with incident CVD, adding combined cancer and CVD DMPs
- C index before adding DMPs
- 0.618 (95% CI: 0.570-0.672)
- C index after adding DMPs
- 0.971 (95% CI: 0.963-0.978)
- n = 950 SHS participants who developed incident CVD
Enrichment analysis
- Interconnected biological pathways involved in cancer and CVD
Original publication
Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence. JACC CardioOncol. Published 10 September 2024. doi:10.1016/j.jaccao.2024.07.014
Summarised from the published abstract; every number is checked against it