Pathological evaluation of predictors for delayed endothelial coverage after currently available drug-eluting stent implantation in coronary arteries: Impact of lesions with acute and chronic coronary syndromes
Authors' conclusion
Endothelial coverage was limited at 90 days after currently available DES implantation, and the ACS culprit site and circumferentially durable polymer-coated DES were identified as independent predictors of delayed endothelial coverage.
Study context
- Population
- Autopsy cases with currently available drug-eluting stent (DES)-stented coronary lesions, implant duration ≤370 days4,713 struts
- Participants
- 66 cases
- Exposure
- Acute coronary syndrome (ACS) vs chronic coronary syndrome (CCS) stented lesions
- ACSn = 40
- CCSn = 26reference
- Outcome
- Predictors of delayed endothelial coverage of DES struts
Methodological detailsautopsy registry, histological evaluation
- Autopsy registry
- Histological evaluation
Main finding
As reported in the abstract
Predictors of delayed endothelial coverage (multivariable logistic regression)
- Implant duration ≤90 days: OR 0.009 (95% CI 0.006-0.012)
- P < .01
- Superficial calcification: OR 0.11 (95% CI 0.07-0.17)
- P < .01
- ACS culprit site: OR 0.29 (95% CI 0.09-0.94)
- P = .039
- Circumferentially durable polymer-coated DES: OR 0.32 (95% CI 0.24-0.41)
- P < .01
Observational data: associations, not effects.
Further findings
Poststent implant duration
P < 0.01
CKD and hemodialysis prevalence
CKD
P = 0.02
Hemodialysis
P = 0.02
Endothelial coverage percentage
- At 30 days
- 3.5%
- At 90 days
- 27.7%
Original publication
Pathological evaluation of predictors for delayed endothelial coverage after currently available drug-eluting stent implantation in coronary arteries: Impact of lesions with acute and chronic coronary syndromes. Am Heart J. Published 8 August 2024. doi:10.
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