Heart failure & cardiomyopathies
Multiomics Insight Into the Role of Glucagon-Like Peptide-1 Receptor Agonists in Heart Failure
Main finding · HF in European populationsResult — go to the resultOdds ratio 0.60 95% CI 0.51–0.72Authors' conclusion
This study provides multiomics insight into the role of GLP1Ra in cardiovascular diseases, especially in HF and the underlying pathway. The results suggest that GLP1Ra may exert anti-HF effects by reducing the concentration of circulating FGF5 and increasing the levels of circulating NAC, and enriches the potential mechanisms through which GLP1Ra alleviates HF.
Study context
- Population
- European and East Asian populations in genome-wide association study data on atrial fibrillation, coronary artery disease, heart failure and ischaemic strokeatrial fibrillation, European 1,202,168 · atrial fibrillation, East Asian 28,612 · coronary artery disease, European 501,756 · coronary artery disease, East Asian 183,134 · heart failure, European 1,350,497 · heart failure, East Asian 203,040 · ischaemic stroke, European 689,168 · ischaemic stroke, East Asian 192,383
- Comparison
- Causal effects of GLP1Ra on cardiovascular diseases in European and East Asian populations
- Outcome
- HF in European populations
Methodological detailsSummary-data-based MR analyses, Mediation analysis, sensitivity analyses
- Summary-data-based MR analyses
- Mediation analysis
- Sensitivity analyses
Main finding
As reported in the abstract
Odds ratio
0.60
95% CI 0.51–0.72
P = 2.76 × 10-8
Further findings
Atrial fibrillation, coronary artery disease, ischaemic stroke in European populations; all cardiovascular diseases in East Asian populations
- No significant associations
Circulating inflammatory proteins and metabolites influenced by GLP1Ra
- Circulating inflammatory proteins influenced
- 27
- Circulating metabolites influenced
- 146
- Inflammatory proteins associated with heart failure (HF)
- 4
- Metabolites associated with HF
- 17
Mediation of the protective effect of GLP1Ra on HF
- Mediated proportion, FGF5
- 4.37%
- Mediated proportion, N-acetylglycine (NAC)
- 8%
Original publication
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