Pulmonary vascular disease & thromboembolism
Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans
Authors' conclusion
MSTI enables noninvasive, contrast-free characterization of thrombus composition and predicts thrombolytic susceptibility.
Study context
- Population
- BALB/C mice with induced IVC venous thrombosis (systemic thrombolysis) and patients with acute iliofemoral DVT undergoing catheter-directed thrombolysis56 mice
- Comparison
- Lysed vs nonlysable thrombi on multisequence thrombus imaging
- Outcome
- Prelysis MSTI parameters (T1, ADC, magnetization transfer) of lysed vs nonlysable thrombi
Methodological detailstranslational (mice and humans), contrast-free
- Translational (mice and humans)
- Contrast-free
Performance
As reported in the abstract
| Test or model | T1 (mice) | ADC (mice) |
|---|---|---|
| Lysed | 723 [667-782] ms | 1.02 [0.96-1.14] ×10-³ mm²/s |
| Nonlysable | 874 [799-1000] ms | 0.78 [0.62-0.88] ×10-³ mm²/s |
T1 (mice)
Lysed723 [667-782] ms
Nonlysable874 [799-1000] ms
ADC (mice)
Lysed1.02 [0.96-1.14] ×10-³ mm²/s
Nonlysable0.78 [0.62-0.88] ×10-³ mm²/s
- Lysed vs Nonlysable: P < 0.001 — mice, T1: 723 [667-782] versus 874 [799-1000] ms
- Lysed vs Nonlysable: P < 0.001 — mice, ADC: 1.02 [0.96-1.14] versus 0.78 [0.62-0.88]
- Lysed vs Nonlysable: P < 0.001 — patients, T1: 606 [543-656] versus 765 [630-909] ms
- Lysed vs Nonlysable: P = 0.001 — patients, ADC: 0.67 [0.5-1.1] versus 1.23 [0.69-1.74]
- Combined multisequence thrombus imaging (MSTI) parameters, mice: sensitivity / specificity
- 88% / 97%
- Combined MSTI parameters, humans: sensitivity / specificity
- 86% / 91%
Original publication
Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans. Circ Cardiovasc Imaging. Published 3 November 2025. doi:10.
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