Myocardial infarction drives trained immunity of monocytes, accelerating atherosclerosis
Authors' conclusion
The findings underscore the crucial role of monocyte trained immunity in accelerated atherosclerosis after MI, implying that SYK in blood classical monocytes may serve as a predictive factor for the progression of atherosclerosis in STEMI patients.
Study context
- Population
- ApoE-/- mice and bone marrow transfer chimeric mice after myocardial infarction (MI) or myocardial ischaemia-reperfusion (IR), with 12-week high-fat diet (HFD); patients (ST-elevation MI (STEMI))
- Outcome
- MI-induced trained immunity of monocytes and atherosclerosis
Main finding
As reported in the abstract
- In MI and IR mice, blood monocytes and bone marrow-derived macrophages showed elevated SYK, KMT5A and CNBP expression upon HFD or oxLDL stimulation
- MI-induced trained immunity transmissible by bone marrow transplantation, accelerating atherosclerosis in naive recipients
- KMT5A recruited H4K20me to the SYK gene body and synergistically transactivated SYK with CNBP
- In vivo small interfering RNA (siRNA) inhibition of KMT5A or CNBP potentially slowed post-MI atherosclerosis
- Sympathetic denervation with 6-hydroxydopamine reduced atherosclerosis and inflammation after MI
- Classical monocytes from STEMI patients with advanced coronary lesions expressed higher SYK and KMT5A gene levels
Original publication
Myocardial infarction drives trained immunity of monocytes, accelerating atherosclerosis. Eur Heart J. Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →