Sex differences in outcomes after acute coronary syndrome vary with age: a New Zealand national study
Authors' conclusion
Men and women admitted with first-time ACS have differing age and comorbidity profiles, resulting in contrasting age-specific sex differences in the risk of adverse outcomes between the youngest and oldest age groups.
Study context
- Population
- People hospitalized for first-time Acute Coronary Syndrome (ACS) in New Zealand, January 2010–December 201640% women
- Participants
- 63,245 people
- Exposure
- Women vs men
- Outcome
- Time to first cardiovascular (CV) readmission or death from discharge
- Follow-up
- 30 days and 2 years
Methodological detailsnational linked health datasets, stratified by sex and 10-year age groups
- National linked health datasets
- Stratified by sex and 10-year age groups
Main finding
As reported in the abstract
Death or CV readmission
Women
- 30-day
- 16%
- 2-year
- 44%
Men
- 30-day
- 12%
- 2-year
- 34%
30-day
Women16%
Men12%
2-year
Women44%
Men34%
Women vs MenHazard ratio (95% CI)
2-year death or CV readmission, aged 18-44 years, unadjusted
1.51(1.21–1.84)
2-year death or CV readmission, aged ≥85 years, unadjusted
0.88(0.83–0.93)
Observational data: associations, not effects.
Secondary outcomes
In-hospital death · unadjusted
P < 0.001
Age at ACS admission
Age at ACS admission
- Higher comorbidity burden in women
Original publication
Sex differences in outcomes after acute coronary syndrome vary with age: a New Zealand national study. Eur Heart J Acute Cardiovasc Care. Published 12 December 2023. doi:10.
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