N-Terminal Pro-Brain Natriuretic Peptide and Cardiorenal Outcome in Patients with Anaemia in Chronic Kidney Disease
Authors' conclusion
NT-proBNP provides prognostic insights into cardiovascular and renal outcomes among patients with advanced chronic kidney disease experiencing anaemia.
Study context
- Population
- Non-dialysis CKD patients with anaemia
- Participants
- 1,484 patients
- Comparison
- Baseline N-terminal pro-brain natriuretic peptide (NT-proBNP) ≥1000 and 500-1000 pg/mL vs <250 pg/mL
- Primary endpoint
- CV outcomes (cardiac death, ACS, HF hospitalization or fatal arrhythmia) and renal outcomes (maintenance dialysis, kidney transplantation, 50% eGFR decrease or eGFR ≤6 mL/min/1.73 m²)
Primary result
As reported in the abstract
CV outcomes · 2.29 ± 0.89 years
Each group vs NT-proBNP <250 pg/mLHazard ratio (95% CI)
NT-proBNP ≥1000 pg/mL
8.10(2.80–23.40)
NT-proBNP 500-1000 pg/mL
3.35(1.10–10.18)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Renal outcomes · 2.29 ± 0.89 yearsNT-proBNP ≥1000 pg/mLvs NT-proBNP <250 pg/mL | 1.77 (1.36–2.31) | |
| Renal outcomes · 2.29 ± 0.89 yearsNT-proBNP 500-1000 pg/mLvs NT-proBNP <250 pg/mL | 1.54 (1.19–2.00) | |
| 0.512Hazard ratio (log scale) |
Renal outcomes · 2.29 ± 0.89 years
- 573 renal events recorded
Baseline NT-proBNP
- Median NT-proBNP, pg/mL (IQR 235.0-1090.0)
- 496.0
- Correlation of log NT-proBNP with estimated glomerular filtration rate (eGFR) (P < 0.001)
- r = −0.131
- Correlation of log NT-proBNP with haemoglobin (Hb) (P < 0.001)
- r = −0.182
- Weak association
Original publication
N-Terminal Pro-Brain Natriuretic Peptide and Cardiorenal Outcome in Patients with Anaemia in Chronic Kidney Disease. ESC Heart Fail. Published 18 December 2024. doi:10.
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