National Trends in Lipid Levels in the United States from 2000 to 2023 Using the Epic Cosmos Database
Authors' conclusion
This study provides a contemporary, real-world, population-level assessment of lipid control and disparities in the United States, providing the first national data on these issues since the COVID-19 pandemic and release of updated cholesterol guidelines.
Study context
- Population
- US individuals with lipid results in the Epic Cosmos EHR database, 2000–2023>175 million results per lipid parameter
- Participants
- 63,600,730 individuals
- Outcome
- Temporal trends in lipid levels and control
- Follow-up
- 2000 to 2023
Methodological detailsEHR database (Epic Cosmos), >250 US health systems
- EHR database (Epic Cosmos)
- >250 US health systems
Main finding
As reported in the abstract
Age-standardized mean LDL-C · 2003, 2013 and 2023
- Males, 2003
- 116.5 mg/dL
- Males, 2013
- 104.1 mg/dL
- Males, 2023
- 102.1 mg/dL
- Females, 2003
- 117.8 mg/dL
- Females, 2013
- 106.1 mg/dL
- Females, 2023
- 105.3 mg/dL
Observational data: associations, not effects.
Further findings
Racial/ethnic disparities in mean TG · 2023
mg/dL
- Variation in mean TG across racial/ethnic groups, up to
- 41.2
- Highest: Hispanic
- 144.2
- Lowest: Black
- 103.0
- Racial/ethnic disparities observed across all lipid parameters
Lipid parameters during the COVID-19 era
- All lipid parameters except HDL-C worsened, disproportionately affecting racial/ethnic minorities
Original publication
National Trends in Lipid Levels in the United States from 2000 to 2023 Using the Epic Cosmos Database. JACC Adv. Published 21 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →