Normative Echocardiographic Left Ventricular Parameters and Reference Intervals in Infants
Authors' conclusion
This study provides normative reference intervals and z-scores for 10 clinical, widely used echocardiographic measures of LV structure and function based on a large cohort of newborns.
Study context
- Population
- Healthy term newborns born to healthy mothers, echocardiogram within 30 days of birth, without congenital heart diseaseCopenhagen Baby Heart Study
- Participants
- 13,454 newborns
- Outcome
- Normative reference intervals and z-scores for 10 2-dimensional echocardiographic left ventricular (LV) parameters, modelled as a function of body surface area
Methodological detailspopulation-based cohort (Copenhagen Baby Heart Study)
- Population-based cohort (Copenhagen Baby Heart Study)
Main finding
As reported in the abstract
- All normative reference intervals performed well in both sexes without stratification on infant sex
- Separate reference models needed for infants examined at <7 days vs 7-30 days of age to optimise performance
Observational data: associations, not effects.
Further findings
Characteristics at examination
- Female
- 48.5%
- Median body surface area
- 0.23 m² (IQR: 0.22-0.25 m²)
- Median age
- 12.0 days (IQR: 8.0-15.0 days)
Original publication
Normative Echocardiographic Left Ventricular Parameters and Reference Intervals in Infants. J Am Coll Cardiol. Published 6 June 2023. doi:10.
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