Prenatal Congenital Heart Disease and Placental Phenotypes: Preserved Neonatal Weight Despite Small Placentas
Authors' conclusion
Infants with CHD have preserved BW and head circumferences in the setting of small placentas and increased prevalence of placental pathology, suggesting placental efficiency.
Study context
- Population
- Live-born singletons with postnatally confirmed congenital heart disease (CHD) with placental pathology
- Participants
- 139 singletons
- Outcome
- Relationship between BW, head circumference, placental weight and placental pathology (PW:BW ratio as placental efficiency) across CHD categories
Main finding
As reported in the abstract
- Birthweight percentile, median
- 33
- Head circumference percentile, median
- 35
- Placental pathology documented
- 37%
- Placental weight (PW):Birthweight (BW) ratio <10th percentile
- 78%
- PW:BW ratio <3rd percentile
- 54%
- No difference in PW:BW <10th percentile between CHD categories
- P = 0.39
- No difference in PW:BW <3rd percentile between CHD categories
- P = 0.56
Observational data: associations, not effects.
Original publication
Prenatal Congenital Heart Disease and Placental Phenotypes: Preserved Neonatal Weight Despite Small Placentas. JACC Adv. Published 30 June 2023. doi:10.
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