Arrhythmias & electrophysiology
New-Onset Left Ventricular Dysfunction After Left Bundle Branch Pacing
Authors' conclusion
NOLVD from reversible causes can occur during follow-up in patients after LBBP.
Study context
- Population
- Patients with successful left bundle branch pacing (LBBP) for symptomatic bradyarrhythmia or as alternative to CRT, with baseline normal or normalized left ventricular (LV) function
- Participants
- 426 patients
- Exposure
- Group I vs Group II
- Group In = 250
- Group IIn = 176
- Outcome
- Incidence and etiology of new-onset LV dysfunction (NOLVD)
- Follow-up
- Mean 28.3 ± 16.7 months
Main finding
As reported in the abstract
NOLVD
Group I
5
events
Group II
11
events
- New-onset left ventricular dysfunction (NOLVD), overall
- 3.75% (n = 16)
Observational data: associations, not effects.
Further findings
Etiology of NOLVD
- Loss of conduction system capture (LOCSC)
- 62.5% (n = 10)
- Suboptimal atrioventricular (AV) delay
- 18.7% (n = 3)
- AF
- 6.3% (n = 1)
- Idiopathic
- 12.5% (n = 2)
Time to LOCSC after implantation
- Mean interval
- 9.2 ± 6.4 months
Reinterventions (lead repositioning, AV delay optimization, AV junction ablation)
- Renormalization of LV function after reintervention
- all 6 patients
Original publication
New-Onset Left Ventricular Dysfunction After Left Bundle Branch Pacing. JACC Clin Electrophysiol. Published 25 September 2024. doi:10.
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