Heart failure & cardiomyopathies
Nocturnal hypoxemic burden in patients with heart failure: Emerging prognostic role of its nonspecific component
Authors' conclusion
By demonstrating a significant independent association of nonspecific hypoxemic burden with all-cause mortality, this study suggests that this component of total nocturnal hypoxemic burden may play an important prognostic role in patients with HFrEF.
Study context
- Population
- Patients with heart failure and reduced ejection fraction (HFrEF)
- Participants
- 280 patients
- Exposure
- Nonspecific vs event-related components of nocturnal hypoxemic burden
- Outcome
- All-cause mortality
- Follow-up
- Median 60 months
Main finding
As reported in the abstract
All-cause mortality, adjusted for known risk factors (Cox regression)
Hazard ratio (95% CI)P value
T90% sleep with SpO2 <90%
1.12(1.02–1.23)
P = 0.018T90Nspecnonspecific component
1.20(1.05–1.37)
P = 0.007Area90area of SpO2 curve below 90%
1.05(1.01–1.10)
P = 0.020Area90Nspecnonspecific component
1.15(1.06–1.25)
P = 0.0006- Deaths
- 87
Observational data: associations, not effects.
Further findings
All-cause mortality, univariate analysis
- T90, Area90 and their components significant
- P < 0.05 all
Original publication
Nocturnal hypoxemic burden in patients with heart failure: Emerging prognostic role of its nonspecific component. Am Heart J. Published 6 July 2024. doi:10.
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