Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis
Pooled result · Composite C/CVDResult — go to the resultSummary relative risk 1.28 95% CI 1.20–1.37Authors' conclusion
We found an overall association between NMGD and C/CVD across all studies. However, estimates from individual studies varied substantially.
Study context
- Population
- Individuals with non-malignant gynaecological diseases (NMGD)28 studies included
- Participants
- 3,271,242 individuals
- Comparison
- Association between NMGD and C/CVD
- Outcome
- Composite C/CVD
Methodological detailsrandom effects models, observational studies
- Random effects models
- Observational studies
Pooled result
As reported in the abstract
Summary relative risk
1.28
95% CI 1.20–1.37
NMGD
SRR 1.28 (95% CI 1.20–1.37)
Further pooled results
Ischaemic heart disease
| SRR (95% CI) | ||
|---|---|---|
| NMGDn=21 studies, I 2 =73.7% | 1.41 (1.31–1.51) | |
| 0.512Summary relative risk (log scale) |
Cerebrovascular disease
| SRR (95% CI) | ||
|---|---|---|
| NMGDn=16 studies, I 2 =91.5% | 1.33 (1.18–1.51) | |
| 0.512Summary relative risk (log scale) |
C/CVD and its components, NMGD-specific analyses
- Risk greater among those with a history of endometriosis or polycystic ovary syndrome
Study selection and risk of bias
- Studies screened
- 6639
- Eligible for full-text review
- 59
- Studies with 'serious'/'critical' risk of bias
- 53.5%
Original publication
Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis. Heart. Published 24 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →