Heart failure & cardiomyopathies
Noninvasive Pressure-Volume Loops Predict Major Adverse Cardiac Events in Heart Failure With Reduced Ejection Fraction
Main finding · MACE by CMR-derived PV loop parametersResult — go to the resultHazard ratio 1.04 95% CI 1.01–1.08Authors' conclusion
Ventricular efficiency, derived from noninvasive PV loop analysis from standard CMR scans, is associated with MACE in patients with HFrEF.
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF) patients (LVEF ≤40%) undergoing clinical cardiovascular magnetic resonance (CMR), 2004–2014
- Participants
- 164 patients
- Outcome
- MACE:
- CV death
- HF hospitalization
- MI
- Revascularization
- VT/VF
- Heart transplantation
- LV assist device implantation
- Follow-up
- Within 5 years
Main finding
MACE by CMR-derived PV loop parameters
Hazard ratio
1.04
95% CI 1.01–1.08
P = 0.01
Ventricular efficiency (per-% decrease)
HR 1.04 (95% CI 1.01–1.08); P = 0.01
Per-% decrease, as printed
As reported in the abstract
- Major adverse cardiac events (MACE) in ≥1 event after average 2.8 years
- 88 (54%)
- Unadjusted: all pressure-volume (PV) loop parameters associated with MACE
- P < 0.05 for all
- Unadjusted: Heart failure (HF) etiology associated with MACE
- P < 0.001
- Unadjusted: LVEF associated with MACE
- P = 0.003
- Unadjusted: global longitudinal strain associated with MACE
- P < 0.001
- Unadjusted: NT-proBNP associated with MACE
- P = 0.001
Observational data: associations, not effects.
Original publication
Noninvasive Pressure-Volume Loops Predict Major Adverse Cardiac Events in Heart Failure With Reduced Ejection Fraction. JACC Adv. Published 4 May 2024. doi:10.
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