Heart failure & cardiomyopathies
Normal standardized left ventricular longitudinal strain curves stratified by age and sex in healthy individuals: the Copenhagen City Heart Study
Authors' conclusion
We established normal sex- and age-specific longitudinal strain curves and furthermore demonstrated their utility by deriving novel measures from these with prognostic value beyond conventional measures. While promising, further validation in external populations is warranted. The normal curves and relevant code are publicly available.
Study context
- Population
- Healthy participants of the Copenhagen City Heart Study (CCHS); external cohort from the LOOP study
- Participants
- 1,641 vs 1,307
- Comparison
- Novel strain-curve measures (EDS, LDS, mean and diastolic strain deviation) against a composite endpoint of cardiovascular death and incident heart failure or atrial fibrillation
- CCHSn = 1,641
- LOOP studyn = 1,307
- Outcome
- Strain curve morphology with age
Methodological detailsinternal validation in the CCHS, external validation in the LOOP study
- Internal validation in the CCHS
- External validation in the LOOP study
Performance
As reported in the abstract
- EDS decreased with age, while LDS increased
Further findings
Composite outcome by mean strain deviation
| Adjusted hazard ratio (95% CI) | P value | ||
|---|---|---|---|
| Mean strain deviationIndependently associated | 1.02 (1.00–1.05) | P = 0.045 | |
| 0.512Adjusted hazard ratio (log scale) |
- Composite of cardiovascular death and incident heart failure or atrial fibrillation (LOOP study) · median follow-up of 4.9 [interquartile interval: 3.0, 5.6] years
- 31.3% · 409 of 1307
Composite outcome by mean strain deviation
- Composite outcome by diastolic strain deviation: diastolic strain deviation was not independently associated with the outcome
Original publication
Normal standardized left ventricular longitudinal strain curves stratified by age and sex in healthy individuals: the Copenhagen City Heart Study. Eur Heart J Cardiovasc Imaging. Published 20 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →