Heart failure & cardiomyopathies
Right ventricular free wall and four-chamber longitudinal strain in relation to incident heart failure in the general population
Authors' conclusion
In participants from the general population, both RVFWLS and RV4CLS were associated with a greater risk of incident HF independent of important baseline characteristics and TAPSE, and LVEF modified the relationship between RV4CLS and incident HF.
Study context
- Population
- General population (5th Copenhagen City Heart Study, 2011–2015) without known chronic ischaemic heart disease or heart failure (HF) at baseline43 (1.6%) developed HF
- Participants
- 2,740 participants
- Exposure
- RVFWLS and RV4CLS and incident HF
- Outcome
- Incident HF
- Follow-up
- Median 5.5 years (IQR 4.5-6.3)
Main finding
As reported in the abstract
median follow-up 5.5 years
Hazard ratio (95% CI)P value
RVFWLS, per 1% absolute decrease
1.06(1.00–1.11)
P = 0.034RV4CLS, per 1% absolute decrease
1.14(1.05–1.23)
P = 0.001Per 1% absolute decrease, as printed
- Participants who developed incident HF
- 43 (1.6%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident HF by RV4CLS, by LVEF (subgroup)RV4CLS, per 1% absolute decrease · LVEF < 55% | 1.21 (1.11–1.33) | P < 0.001 | |
| Incident HF by RV4CLS, by LVEF (subgroup)RV4CLS, per 1% absolute decrease · LVEF ≥ 55% | 0.94 (0.80–1.10) | P = 0.43 | |
| 0.512Hazard ratio (log scale) |
- Incident HF by RV4CLS, by left ventricular ejection fraction (LVEF) (subgroup): P for interaction = 0.016
Original publication
Right ventricular free wall and four-chamber longitudinal strain in relation to incident heart failure in the general population. Eur Heart J Cardiovasc Imaging. Published 25 October 2023. doi:10.
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