Heart failure & cardiomyopathies
Link between myocardial deformation phenotyping using longitudinal and circumferential strain and risk of incident heart failure and cardiovascular death
Authors' conclusion
The prognostic utility of GCS is modified by LVEF. In participants with normal LVEF, higher GCS was associated with increased risk of HF/CD, while the opposite was observed in participants with abnormal LVEF.
Study context
- Population
- Participants of the 5th Copenhagen City Heart Study (2011–15) examined with echocardiography73 developed heart failure (HF)/cardiovascular death (CD)
- Participants
- 2,874 participants
- Exposure
- Global circumferential strain (GCS) phenotyping and risk of HF/CD
- Outcome
- Incident HF or CV death (HF/CD)
- Follow-up
- Median 3.5 years
Methodological detailsMean age 53±18 years; 60% female
- Mean age 53±18 years; 60% female
Main finding
As reported in the abstract
HF/CD per 1% change in GCS, by LVEF
Hazard ratio (95% CI)
LVEF ≥ 50%per 1% increase in GCS; multivariable Cox
1.12(1.02–1.23)
LVEF < 50%per 1% decrease in GCS; multivariable Cox
1.18(1.05–1.31)
Each row per its own increment, as printed
- LV ejection fraction (LVEF) modified GCS–HF/CD association; optimal transition point LVEF < 50%
- P for interaction < 0.001
Observational data: associations, not effects.
Original publication
Link between myocardial deformation phenotyping using longitudinal and circumferential strain and risk of incident heart failure and cardiovascular death. Eur Heart J Cardiovasc Imaging. Published 20 April 2023. doi:10.
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