Pulmonary vascular disease & thromboembolism
One-minute sit-to-stand test cut-offs for risk stratification based on six-minute walk test thresholds in pulmonary hypertension
Authors' conclusion
The 1-min STST cut-offs aligning with the 6MWT thresholds of 165 and 440 m are 14 and 20 repetitions, respectively. Patients performing ≤14 repetitions demonstrated worse clinical parameters and higher mortality rates, making the 1-min STST a potential risk stratification tool in PH patients.
Study context
- Population
- Patients with pulmonary hypertension (mean age 66 ± 14 years, 57% female)
- Participants
- 114 patients
- Comparison
- 1-min STST cut-offs vs guideline 6MWT thresholds
- Outcome
- 1-min STST cut-offs aligning with 6MWT thresholds (165 and 440 m) by ROC analysis
Performance
As reported in the abstract
1-min STST cut-offs vs 6MWT thresholds
| Strategy | AUC (95% CI) | Sensitivity (<165 m) | Sensitivity (>440 m) | Specificity (<165 m) | Specificity (>440 m) |
|---|---|---|---|---|---|
| ≤14 repetitions | 0.90 (0.84-0.97) | 69% | — not stated in the abstract | 100% | — not stated in the abstract |
| ≥20 repetitions | 0.85 (0.75-0.94) | — not stated in the abstract | 81% | — not stated in the abstract | 84% |
AUC (95% CI)
≤14 repetitions0.90 (0.84-0.97)
≥20 repetitions0.85 (0.75-0.94)
Sensitivity (<165 m)
≤14 repetitions69%
≥20 repetitions— not stated in the abstract
Sensitivity (>440 m)
≤14 repetitions— not stated in the abstract
≥20 repetitions81%
Specificity (<165 m)
≤14 repetitions100%
≥20 repetitions— not stated in the abstract
Specificity (>440 m)
≤14 repetitions— not stated in the abstract
≥20 repetitions84%
— not stated in the abstract
Further findings
Clinical characteristics and mortality, ≤14 vs ≥20 repetitions
- Worse NT-proBNP with ≤14 repetitions
- P < 0.001
- Worse WHO functional class with ≤14 repetitions
- P < 0.001
- Worse mean pulmonary artery pressure with ≤14 repetitions
- P = 0.050
- Worse health-related quality of life with ≤14 repetitions
- P < 0.001
- Higher mortality with ≤14 vs ≥20 repetitions
- P = 0.020
Cohort performance
- 1-min STST repetitions, mean ± SD
- 17 ± 6
- 6MWT distance, mean ± SD
- 354 ± 133 m
Original publication
One-minute sit-to-stand test cut-offs for risk stratification based on six-minute walk test thresholds in pulmonary hypertension. Eur J Prev Cardiol. Published 25 January 2025. doi:10.
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