Acute cardiac care & resuscitation
Optimal ECLS Support in Mixed Cardiogenic and Septic Shock: An ELSO Registry Analysis
Main finding · Survival to dischargeResult — go to the resultAdjusted odds ratio 1.31 95% CI 0.87–1.97Authors' conclusion
Patients with mixed shock requiring VA-ECLS have a high mortality. Patients with mixed shock receiving higher support at 24 hours had a trend toward increased survival to discharge compared to those with lower support.
Study context
- Population
- Adults (age >18 years) in mixed cardiogenic and septic shock requiring veno-arterial extracorporeal life support (VA-ECLS), ELSO database, 2017–2022
- Participants
- 452 adults
- Exposure
- Higher vs lower VA-ECLS support at 24 hours
- Outcome
- Survival to discharge
Methodological detailsregistry-based (ELSO database)
- Registry-based (ELSO database)
Main finding
As reported in the abstract
24 hours
Adjusted odds ratio
1.31
95% CI 0.87–1.97
P = 0.19
By group
Higher VA-ECLS flow (continuous)
aOR 1.31 (95% CI 0.87–1.97); P = 0.19
Observational data: associations, not effects.
Further findings
Factors associated with increased mortality (multivariable)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Older age | 1.02 (1.01–1.04) | P < 0.001 | |
| Pre-extracorporeal membrane oxygenation cardiac arrest | 1.71 (1.11–2.65) | P = 0.016 | |
| Baseline Charlson Comorbidity Index | 1.13 (1.01–1.28) | P = 0.043 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Survival to discharge, VA-ECLS flow at 24 h as continuous variable
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Higher VA-ECLS flow at 24 hContinuous variable | 1.31 (0.87–1.97) | P = 0.19 | |
| 0.512Adjusted odds ratio (log scale) |
Overall mortality
- Overall mortality (n = 285)
- 63%
Original publication
Optimal ECLS Support in Mixed Cardiogenic and Septic Shock: An ELSO Registry Analysis. JACC Adv. Published 23 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →