Arrhythmias & electrophysiology
Optimizing the Distribution of Ablation Lesions to Prevent Postablation Atrial Tachycardia: A Personalized Digital-Twin Study
Authors' conclusion
Personalized atrial DTs enable preprocedure prediction of iAT occurrence after ablation in the fibrotic substrate.
Study context
- Population
- Patients with persistent atrial fibrillation (AF); LGE-MRI-based biatrial digital twins28 digital twins (DTs) with reentry-sustaining sites
- Participants
- 37 patients
- Comparison
- MRA vs SSA ablation in digital twins
- Outcome
- Postablation iatrogenic scar-related atrial tachycardia (iAT) occurrence
Methodological detailscomputational simulation (biatrial digital twins), prospectively enrolled patients
- Computational simulation (biatrial digital twins)
- Prospectively enrolled patients
Main finding
As reported in the abstract
iAT occurrence
Reentry-sustaining fibrotic locations targeted for SSA
83
SSA ablations resulting in iAT
45
Locations where MRA prevented iAT
15
Reduction in rate of iAT occurrence with MRA
18%
Original publication
Optimizing the Distribution of Ablation Lesions to Prevent Postablation Atrial Tachycardia: A Personalized Digital-Twin Study. JACC Clin Electrophysiol. Published 4 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it