Heart failure & cardiomyopathies
Organ perfusion pressure at admission and clinical outcomes in patients hospitalized for acute heart failure
Authors' conclusion
In this retrospective analysis on patients hospitalized for AHF treated with sodium nitroprusside, on-admission OPP significantly predicted WHF at 48 h with high sensitivity.
Study context
- Population
- Patients hospitalised for acute HF treated with sodium nitroprusside, with mean arterial pressure (MAP) and invasive central venous pressure (CVP) dataof 200 in SNIP-AHF
- Participants
- 146 patients
- Primary endpoint
- OPP as a predictor of WHF (worsening of HF signs and symptoms leading to intensification of therapy)
- Follow-up
- 48 h
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
WHF predicted by on-admission OPP
- Worsening heart failure (WHF) incidence
- 14 (9.6%)
- Organ perfusion pressure (OPP) at admission, multivariable OR for WHF (per mmHg), 95% CI 0.86-0.96, P-value = 0.001
- 0.91
- Optimal OPP cut-off
- 67.5 mmHg
- Specificity
- 47.3%
- Sensitivity
- 100%
- AUC
- 0.784 ± 0.054
Further findings
OPP in multivariable model with NYHA class, shock index, CVP, LV end-diastolic diameter · 48 h
- OPP consistently and significantly predicted WHF
Original publication
Organ perfusion pressure at admission and clinical outcomes in patients hospitalized for acute heart failure. Eur Heart J Acute Cardiovasc Care. Published 26 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →