Heart failure & cardiomyopathies
Liver Stiffness Measurement for Non-Invasive Assessment of Central Venous Pressure in Patients with Heart Failure: A Multicentre Pilot Study
PerformanceResult — go to the resultMean difference 0.11 mmHg 95% CI −1.31 to 1.54Authors' conclusion
Liver stiffness measurement is a promising non-invasive surrogate for CVP in patients with HF.
Study context
- Population
- Patients aged 18 to 85 years with heart failure (HF) (or LVEF ≤40%) requiring central venous line placement with central venous pressure (CVP) measurement38 completed
- Comparison
- Non-invasive liver stiffness measurement (LSM)-derived CVP vs invasive catheter CVP
- Outcome
- Agreement between CVP and LSM-derived CVP in the supine position
Methodological detailsmulticentre, pilot, open-label
- Multicentre
- Pilot
- Open-label
Performance
As reported in the abstract
Mean difference
0.11 mmHg
95% CI −1.31 to 1.54
Invasive CVPvs LSM
mean difference 0.11 mmHg (95% CI −1.31 to 1.54)
- Correlation of CVP with LSM-derived CVP (Spearman r)
- 0.53, p < 0.001
Further findings
| Outcome | LSM |
|---|---|
| Detection of clinically significant CVP elevation (>10 mmHg) | |
| AUC | 0.83 |
| Sensitivity (LSM >10 kPa) | 0.73 |
| Specificity (LSM >10 kPa) | 0.78 |
| Correctly classified (LSM >10 kPa) | 76% |
Original publication
Liver Stiffness Measurement for Non-Invasive Assessment of Central Venous Pressure in Patients with Heart Failure: A Multicentre Pilot Study. Eur J Heart Fail. Published 16 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →