Heart failure & cardiomyopathies
Outcome Prediction by Myocardial External Efficiency from 11C-Acetate Positron Emission Tomography in Cardiac Amyloidosis
Performance · Survival prediction by 11C-acetate PET parametersResult — go to the resultHazard ratio 0.56 per 0.1 mL/g 95% CI 0.39–0.81Authors' conclusion
Reduced MEE was associated with shorter survival in CA patients, but FSV/LVM was the strongest survival predictor and the only independently prognostic 11 C-acetate PET parameter in multivariate analysis.
Study context
- Population
- Patients with cardiac amyloidosis (ATTR and AL) examined with 11C-acetate positron emission tomography (PET) and echocardiography
- Participants
- 48 vs 20
- Comparison
- Cardiac amyloidosis (CA) patients vs controls; deceased vs surviving CA patients
- CAn = 48
- Controlsn = 20reference
- Outcome
- Prognostic value of MVO2 and MEE from 11C-acetate PET for survival
Performance
As reported in the abstract
Survival prediction by 11C-acetate PET parameters
Hazard ratio
0.56 per 0.1 mL/g
95% CI 0.39–0.81
P = 0.002
FSV/LVM
HR 0.56 per 0.1 mL/g (95% CI 0.39–0.81); P = 0.002
Per 0.1 mL/g, as printed
- Myocardial external efficiency (MEE) cut-off 15.7% separated deceased from surviving CA patients
- P = 0.032
- Survival significantly shorter with forward stroke volume (FSV)/left ventricular mass (LVM) below 0.27 mL/g, also separately in AL- and ATTR-CA
- P < 0.001
Further findings
Univariate prognostic factors
- NYHA class, NT-proBNP, FSV/LVM and MEE were the strongest prognostic factors
Original publication
Outcome Prediction by Myocardial External Efficiency from 11C-Acetate Positron Emission Tomography in Cardiac Amyloidosis. ESC Heart Fail. Published 8 October 2023. doi:10.
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