Outcomes According to Coronary Revascularization Modality in the ISCHEMIA Trial
Authors' conclusion
In ISCHEMIA, early revascularization by PCI and CABG was associated with higher early risks and lower long-term risks of cardiovascular events compared with CON. The early risk was greatest after CABG, owing to protocol-defined procedural MIs.
Study context
- Population
- Patients with stable CAD without preceding primary outcome events
- Participants
- 512 / 1,500 / 2,591
- Comparison
- INV-PCI and INV-CABG vs conservative (CON)
- CABGn = 512
- Percutaneous coronary intervention (PCI)n = 1,500
- CONn = 2,591reference
- Primary endpoint
- ISCHEMIA primary outcome:
- CV death
- Protocol-defined MI or hospitalization for unstable angina
- HF
- Resuscitated cardiac arrest
Primary result
As reported in the abstract
ISCHEMIA primary outcome:
- CV death
- MI
- Hospitalization for unstable angina
- HF
- Resuscitated cardiac arrest
Each group vs CONHazard ratio (95% CI)
CABGadjusted; within 30 days
16.25(11.44–23.07)
PCIadjusted; within 30 days
2.99(1.97–4.53)
CABGadjusted; after 30 days
0.63(0.44–0.89)
PCIadjusted; after 30 days
0.66(0.53–0.82)
Original publication
Outcomes According to Coronary Revascularization Modality in the ISCHEMIA Trial. J Am Coll Cardiol. Published 11 November 2023. doi:10.
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