Outcomes by sex in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial
Authors' conclusion
In ISCHEMIA, women assigned to the INV arm were less likely to undergo revascularisation than men. The effect of an INV versus CON strategy was consistent by sex, but women had a significantly lower contribution of procedural MI to the primary outcome.
Study context
- Population
- Participants with stable CAD in the ISCHEMIA trial; analysed by sex1,168 (22.6%) women
- Participants
- 5,179 participants
- Comparison
- Invasive (INV) vs conservative (CON) strategy, by participant sex
- Primary endpoint
- ISCHEMIA primary composite outcome:
- CV death
- Any MI or rehospitalisation for unstable angina
- HF
- Resuscitated cardiac arrest
Methodological detailssubgroup analysis by sex
- Subgroup analysis by sex
Primary result
As reported in the abstract
Primary composite outcome, INV vs CON, by sex
INV vs CONHazard ratio (95% CI)
Women
0.96(0.70–1.33)
Men
0.90(0.76–1.07)
Further findings
Revascularisation in INV-assigned participants, by sex
| Adjusted OR (95% CI) | P value | ||
|---|---|---|---|
| Female sex | 0.75 (0.57–0.99) | P = 0.04 | |
| 0.512Adjusted odds ratio (log scale) |
Procedural MI contribution to primary outcome, by sex
P = 0.01
Denominator Women 151 · Men 519
- Revascularisation in INV-assigned participants, by sex: female sex independently associated with lower likelihood of revascularisation
Procedural MI contribution to primary outcome, by sex
- Contribution of other individual components similar between sexes
Original publication
Outcomes by sex in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial. EuroIntervention. Published 10 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →