Predictors of late lumen enlargement after drug-coated balloon angioplasty for de novo coronary lesions
Authors' conclusion
Layered plaques and extensive medial dissection after DCB angioplasty were associated with higher LLE occurrence in de novo coronary lesions.
Study context
- Population
- Patients with angina pectoris treated with paclitaxel-coated balloon angioplasty without stenting for de novo coronary lesions, under optical frequency domain imaging (OFDI) guidance with follow-up OFDI
- Participants
- 83 patients108 lesions
- Outcome
- Late lumen enlargement (≥10% increase in lumen volume of treated lesion at follow-up); predictive lesion characteristics
- Follow-up
- Median 6.1 months
Methodological detailssingle-centre, serial OFDI, Between August 2016 and December 2019
- Single-centre
- Serial OFDI
- Between August 2016 and December 2019
Main finding
As reported in the abstract
Independent predictors of LLE (multivariate analysis)
Odds ratio (95% CI)P value
Layered plaques
8.73(1.92–39.7)
P = 0.005Medial dissection with arc >90°
4.65(1.63–13.3)
P = 0.004- Late lumen enlargement (LLE) detected
- 44 (40.7%) lesions
Observational data: associations, not effects.
Further findings
Lumen volume at follow-up vs post-procedure, by plaque phenotype
- Fibrous/fibrocalcific and layered plaques: significantly larger lumen volumes at follow-up
- Lipid plaques: no significant difference
- Medial dissection with arc >90°: increased lumen volume
Original publication
Predictors of late lumen enlargement after drug-coated balloon angioplasty for de novo coronary lesions. EuroIntervention. Published 10 May 2024. doi:10.
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