Valvular & structural heart disease
Outcomes of complex, high-risk percutaneous coronary intervention in patients with severe aortic stenosis: the ASCoP registry
Authors' conclusion
In patients undergoing TAVI and complex/high-risk PCI, a concomitant strategy is associated with a higher rate of adverse events and increased procedural risk. (ClinicalTrials.gov: NCT05750927).
Study context
- Population
- Patients with a clinical indication for both transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) with at least 1 criterion of complex or high-risk PCIpatients included
- Participants
- 519 patients
- Exposure
- Concomitant TAVI and PCI vs staged procedures
- Concomitant TAVI and PCIn = 156
- Staged proceduresn = 363
- Outcome
- Composite of:
- All-cause death
- Unplanned rehospitalisation for cardiovascular causes
- Follow-up
- 441 (interquartile range 182-824) days
Methodological detailsretrospectively included, multivariable analysis
- Retrospectively included
- Multivariable analysis
Main finding
As reported in the abstract
Primary endpoint occurred, overall
151
36.5%
Observational data: associations, not effects.
Secondary outcomes
Secondary endpoint: composite of all-cause death, stroke, acute myocardial infarction, major bleeding, major vascular complication and unplanned revascularisation · 441 (interquartile range 182-824) days · occurred more frequently in the concomitant group
P = 0.014
Original publication
Outcomes of complex, high-risk percutaneous coronary intervention in patients with severe aortic stenosis: the ASCoP registry. EuroIntervention. Published 21 April 2025. doi:10.
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