Valvular & structural heart disease
Outcomes of Transcatheter Aortic Valve Replacement in Asymptomatic or Minimally Symptomatic Aortic Stenosis
Main finding · DeathResult — go to the resultAdjusted hazard ratio 0.70 95% CI 0.66–0.75Authors' conclusion
Although minimally symptomatic patients treated with TAVR experience only small improvements in health status, their overall outcomes are favorable with a higher likelihood of survival with good health status at 1 year compared with more symptomatic patients.
Study context
- Population
- Patients with severe AS and normal LVEF undergoing transcatheter aortic valve replacement (TAVR), 2015–202120.0% minimally symptomatic
- Participants
- 231,285 patients
- Exposure
- Minimally symptomatic vs moderate or severe symptoms before TAVR
- Outcome
- Death
- Follow-up
- 1 year
Methodological detailsSTS/ACC TVT registry
- STS/ACC TVT registry
Main finding
As reported in the abstract
Adjusted hazard ratio
0.70
95% CI 0.66–0.75
Minimally symptomaticvs Moderate or severe symptoms
adjusted HR 0.70 (95% CI 0.66–0.75)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Alive and well · 1 year | 1.19 (1.16–1.23) | |
| 0.512Odds ratio (log scale) |
Mean increase, points
| Outcome | Minimally symptomatic | Moderate or severe symptoms |
|---|---|---|
| Change in mean KCCQ-OS · 30 days | 2.7 (95% CI 2.6–2.9) | 32.2 (95% CI 32.0–32.3) |
| Change in mean KCCQ-OS · 1 year | 3.8 (95% CI 3.6–4.0) | 34.9 (95% CI 34.7–35.0) |
Original publication
Outcomes of Transcatheter Aortic Valve Replacement in Asymptomatic or Minimally Symptomatic Aortic Stenosis. JACC Cardiovasc Interv. Published 20 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →