Heart failure & cardiomyopathies
Outpatient Treatment of Decompensated Heart Failure: A Systematic Review and Study Level Meta-Analysis
Pooled result · 30 day all-cause mortalityResult — go to the resultOdds ratio 0.29 95% CI 0.09–0.93Authors' conclusion
In observational studies, OPM of ADHF is associated with lower 30 day hospitalization and lower 30 day mortality; such differences were not observed in two small, single-centre RCTs.
Study context
- Population
- Patients with acutely decompensated heart failure (ADHF)
- Participants
- 7,683 patients · 29 studies
- Comparison
- Outpatient management vs inpatient management of ADHF
- OPMn = 1,303
- Inpatient management (IPM)n = 2,047reference
- Outcome
- 30 day mortality and 30 day hospitalization
- Follow-up
- 30 days
Methodological detailsstudy-level
- Study-level
Pooled result
30 day all-cause mortality
Odds ratio
0.29
95% CI 0.09–0.93
P = 0.04
Events by group
OPM vs IPM
OR 0.29 (95% CI 0.09–0.93); P = 0.04
As reported in the abstract
Further pooled results
| Outcome | OPM | IPM | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| 30 day all-cause hospitalization · 4 studies | 16.8% | 22.0% | 0.73 (0.61–0.89) | P = 0.001 | |
| 0.512Odds ratio (log scale) |
30 day mortality and hospitalization in the 2 randomized controlled trials (RCTs)
- No difference in 30 day mortality or hospitalization
Original publication
Outpatient Treatment of Decompensated Heart Failure: A Systematic Review and Study Level Meta-Analysis. ESC Heart Fail. Published 16 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it