Arrhythmias & electrophysiology
Overlooked and Underdiagnosed: Cardiac Sarcoidosis and Unexplained Ventricular Tachycardia and Fibrillation
Authors' conclusion
Despite established guidelines, testing for CS remains underutilized in patients with unexplained VT/VF.
Study context
- Population
- Adults (≥18 y) with unexplained ventricular tachycardia (VT)/ventricular fibrillation (VF) requiring ICD implantation over the past 5 years
- Participants
- 732 adults
- Outcome
- Proportion undergoing guideline-based evaluation for cardiac sarcoidosis (CMR, PET, chest CT, myocardial biopsy)
- Follow-up
- 5-year follow-up
Methodological detailsmulticentre (56 healthcare organizations), TriNetX data, Mean age 53 ± 19 years; 61% male; mean follow-up 827 days
- Multicentre (56 healthcare organizations)
- TriNetX data
- Mean age 53 ± 19 years; 61% male; mean follow-up 827 days
Main finding
As reported in the abstract
Use of diagnostic modalities for cardiac sarcoidosis
CMR performed: 146 patients, 95% CI 17.21%-22.99%
19.9%
Cardiac PET performed: 17 patients, 95% CI 1.45%-3.69%
2.3%
Chest CT performed: 54 patients, 95% CI 5.70%-9.50%
7.4%
Myocardial biopsy performed: <10 patients, 95% CI 0.74%-2.50%
1.4%
Observational data: associations, not effects.
Further findings
- Sarcoidosis diagnosed: <10 patients, 95% CI 0.74%-2.50%
- 1.4%
Original publication
Overlooked and Underdiagnosed: Cardiac Sarcoidosis and Unexplained Ventricular Tachycardia and Fibrillation. JACC Adv. Published 27 October 2025. doi:10.
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