Arrhythmias & electrophysiology
Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement
Authors' conclusion
In patients with suspected cardiac sarcoidosis, CMR phenotyping showed greater discriminative accuracy than societal recommendations for predicting fatal or life-threatening ventricular arrhythmias
Study context
- Population
- Patients with histology-supported sarcoidosis undergoing CMR for suspected cardiac involvement, ineligible for secondary prevention implantable cardioverter-defibrillators (ICDs)84 with outcome
- Participants
- 1,514 patients
- Exposure
- CMR phenotyping vs societal recommendations for primary prevention ICD placement
- Outcome
- Composite of:
- Fatal
- Life-threatening ventricular arrhythmias
- Follow-up
- Median 4.5 years; maximum 10 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Fatal or life-threatening ventricular arrhythmias (composite) · 5 and 10 years
| Outcome | High-risk CMR phenotype | Low-risk CMR phenotype | Societal recommendations | |
|---|---|---|---|---|
| 5-year incidence | 24.0% | 0.7% | Not reported in the abstract | Societal recommendations: not reported in the abstract |
| 10-year incidence | 35.0% | 2.6% | Not reported in the abstract | Societal recommendations: not reported in the abstract |
Observational data: associations, not effects.
Original publication
Prediction of ventricular arrhythmic outcomes in suspected cardiac sarcoidosis: a comparison of cardiovascular magnetic resonance phenotyping vs. societal recommendations for implantable cardioverter-defibrillator placement. Eur Heart J. Published 22 May 2025. doi:10.
Summarised from the published abstract; every number is checked against it